About me & Custom DNA Constructs

After years in academic biological research (see publication list below; LinkedIn profile) I established Custom DNA Constructs in 2011. Cloning is my passion and expertise, I take personal responsibility and pride in executing and completing every project. Many times this requires development of new cloning schemes which in turn increases my capabilities for solving complex cloning situations.  While in academy, it seemed unfair to me when companies sometimes inflated pricing and I now attempt to offer my customers fair and affordable price. Read what my customers say about my cloning service (testimonials).

Nahum Meller, PhD. Custom DNA Constructs

My Publications

  1. Meller J, Rogozin IB, Poliakov E, Meller N, Bedanov-Pack M, Plow EF, Qin J, Podrez EA, Byzova TV. Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness.Mol Biol Cell. 2015 Feb 15;26(4):786-96.
  2. Meller N, Morgan ME, Wong WP, Altemus JB, Sehayek E. Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption. Lipids Health Dis. (Jun 2013) 14;12:88.
  3. Liu, Y., Liu, Y.C., Meller, N., Giampa, L., Elly, C., Doyle, M., Altman, A. Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins. J. Immunol. 162(12) (Jun. 1999): 7095-7101.
  4. Cutchins A, Harmon DB, Kirby JL, Doran AC, Oldham SN, Skaflen M, Klibanov AL, Meller N, Keller SR, Garmey J, McNamara CA.   Inhibitor of Differentiation-3 Mediates High Fat Diet-Induced Visceral Fat Expansion. (Nov. 2011) Arterioscler. Thromb. Vasc.
  5. Deshmukh L, Meller N, Alder N, Byzova T, Vinogradova O. Tyrosine Phosphorylation as a Conformational Switch: A CASE STUDY OF INTEGRIN β3 CYTOPLASMIC TAIL.(Nov. 2011) J. Biol. Chem. 286(47):40943-53.
  6. Deliri H, Meller N, Kadakkal A, Malhotra R, Brewster J, Doran AC, Pei H, Oldham SN, Skaflen MD, Garmey JC, McNamara CA. Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury.   Arterioscler (Jan. 2011) Thromb Vasc Biol. 31(1):110-6.
  7. Doran AC, Lehtinen AB, Meller N, Lipinski MJ, Slayton RP, Oldham SN, Skaflen MD, Yeboah J, Rich SS, Bowden DW, McNamara CA.   Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. (Apr. 2010)   Circ Res. 106(7):1303-11.
  8. Brown, K. A., Ham A. L., Clark, C. N., Meller, N., Law, B. K., Chytil, A., Cheng, N., Pietenpol, J. A., Moses, H. L. Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1. J. Cell. Biochem. 105(2) (Oct. 2008): 596-611. PMCID: 2700048.
  9. Doran, A.C., Meller, N., Cutchins, A., Deliri, H., Slayton, R. P., Oldham, S. N., Kim, J. B., Keller, S. R., McNamara, C. M. The Helix-Loop-Helix Factors Id3 and E47 are Novel Regulators of Adiponectin. Circ. Research 103(6) (Sept. 2008): 624-634. PMCID: 2746666.
  10. Doran, A.C., Meller, N., McNamara, C.A. Role of Smooth Muscle Cells in the Initiation and Early Progression of Atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 28(5) (May 2008): 812-819. PMCID: 2734458
  11. Meller, N., Westbrook, M.J., Shannon, J.D., Guda, C., Schwartz, M.A. Function of the N-terminus of zizimin1: autoinhibition and membrane targeting. Biochem. J. 409(2) (Jan. 2008): 525-533. PMCID: 2740492
  12. Moissoglu, K., Slepchenko, B. M., Meller, N., Horwitz, A. F. Schwartz, M. A. In Vivo Dynamics of Rac-Membrane Interactions. Mol. Biol. Cell. 17(6) (Jun. 2006): 2770-2779.
  13. Meller, N., Merlot, S., Guda, C. CZH Proteins: a new family of Rho GEFs. J. Cell Sci. 118(Pt. 2) (Nov. 2005): 4937-4946.
  14. Nishikimi, A., N., Meller, N., Uekawa, K. I. Isobec, M. A. Schwartz, M. A. Maruyama, M. Zizimin2: a novel, DOCK180-related Cdc42 Guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett. 579(5) (Feb. 2005): 1039-1046.
  15. Meller, N., Irani-Tehrani, M., Ratnikov, B.I., Paschal, B.M. Schwartz, M.A. The novel Cdc42 Guanine nucleotide Exchange Factor, zizimin1, dimerizes via the Cdc42- binding CZH2 domain. J. Biol. Chem. 279(36) (Sept. 2004): 37470-37476.
  16. Meller, N., Irani-Tehrani, M., Kiosses, W.B., Del Pozo, M.A. Schwartz, M.A. Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. Nature Cell Biol. 4(9) (Sept. 2002): 639-647.
  17. Del Pozo, M.A., Kiosses, W.B., Alderson, N.B., Meller, N., Hahn, K.M. & Schwartz, M.A. Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Nat. Cell Biol. 4(3) (Mar. 2002): 232-239.
  18. Meller, N., Elitzur, Y., Isakov, N. Protein kinase C-theta distribution analysis in hematopoietic cells: proliferating T cells exhibit high proportions of PKC theta in the particulate fraction. Cell. Immunol. 193(2) (May 1999): 185-193.
  19. Liu, Y., Liu, Y.C., Meller, N., Giampa, L., Elly, C., Doyle, M., Altman, A. Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins. J. Immunol. 162(12) (Jun. 1999): 7095-7101.
  20. Meller, N., Altman, A. Isakov, N. New perspectives on PKC theta, a member of the novel subfamily of protein kinase C. Stem Cells 16(3) (1998): 178-192.
  21. Meller, N., Liu, Y.C., Collins, T.L., Bonnefoy-Berard, N., Baier, G., Isakov, N. Altman, A. Direct interaction between protein kinase C theta (PKC theta) and 14-3- 3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. Mol. Cell. Biol. 16(10) (Oct. 1996): 5782-5791.
  22. Bonnefoy-Berard, N., Munshi, A., Yron, I., Wu, S., Collins, T.L., Deckert, M., Shalom- Barak, T., Giampa, L., Herbert, E., Hernandez, J., Meller, N., Couture, C. & Altman, A. Vav: function and regulation in hematopoietic cell signaling. Stem Cells 14(3) (May 1996): 250-268.
  23. Fraser, G.M., Harman, I., Meller, N., Niv, Y. & Porath, A. Diabetes mellitus is associated with chronic hepatitis C but not chronic hepatitis B infection. Isr. J. Med.Sci. 32(7) (Jul. 1996): 526-530.